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Purpose: This study was performed to clarify the possibility of bone regeneration with a cell-hybridized artificial bone by evaluating bone formation in the beagle dog femur.Methods: Bone marrow stromal cells (BMSCs) /interconnected porous hydroxyapatite (IP-CHA) composites as a cell-hybridized artificial bone were made by the injection of the BMSCs solution into IP-CHA. The distribution of BMSCs in IP-CHA was examined by scanning electron microscopy. Two BMSCs/IP-CHA composites (the BMSCs of one composite were labeled fluorescence) were placed into each of two bone sockets (φ3.7 mm×7 mm) prepared in the right femur of the beagle dog. After 4 weeks of surgery, new bone formation in the socket was examined by light microscopy and fluorescence microscopy.Results: SEM showed well distribution of the injected BMSCs in the pores of IP-CHA. At 4 weeks, new bone formation was detected at the cortical areas of the composites, and injected BMSCs were identified in the new bone area of the interconnected pores. Conclusion: The limited results of this study may suggest that BMSCs/IP-CHA composites as cell-hybridized artificial bone is a possible candidate for bone regeneration.

prosthodontic research and practice

A Preliminary Study on a Newly Developed Cell-hybridized Artificial Bone in a Beagle Dog: Bone Marrow Stromal Cells with an Interconnected Porous Hydroxyapatite Scaffold