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Bone Morphogenetic Protein (BMP) induces the differentiation of the mesenchymal cells into the osteoblastic cells in vivo.The purpose of this study is to carry out early bone formation and more rigid support of the dental implant after insertion of it with BMP.In this study, the BMP fraction was extracted from the bovine cortex bone and purified by means of gel filtration. The partially purified BMP was combined with a rough surfaced implant (trial production) and inserted in the dog mandible. After insertion, the effect of BMP was evaluated by removable torque strength, rate of bone contact with implant surface and histomorphometric investigation.As a result of the application of BMP to dental implants, supporting strength of mandibular bone was advanced and bone formation between bone and implant surface was promoted at 2 weeks after implantation. However at 8 weeks after implantation, the implants with BMP were not different form unapplied groups concerning bone formation.

Experimental Study on Application of Bone Morphogenetic Protein to Dental Implant. As to the Hydroxyapatite Implant.