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RAD 544. Medical Sciences 52-53 (2020) : 84-87 www.rad-med.com 84 December 2020 Vol 544 = 52-53 Abstract Leptomeningeal carcinomatosis is an uncommon complication of different types of cancer in which the disease spreads to meninges. It usually presents with clinical features of meningeal irritation, combined with cranial nerve involvement. This report aims to describe vestibular dysfunction as one of the possible and infrequent initial signs of leptomeningeal carcinomatosis. We present a case of a 49-year-old female that has been previously diagnosed breast cancer who developed bilateral vestibular dysfunction due to leptomeningeal carcinomatosis. Leptomeningeal carcinomatosis can be variable in its presentation since any aspect of the nervous system can be affected. Multiple cranial nerve involvement isn’t rare, with most commonly affected third, fifth and seventh cranial nerve (5). In our case, the patient presented with the symptoms of isolated vestibular dysfunction with preserved cochlear part of the nerve. This can be explained by the possible way of propagation of malignant cells via endolymphatic ductus into the inner ear with the obliterated connection between sacculus and cochlea.

Isolated vestibular dysfunction as an initial manifestation of leptomeningeal carcinomatosis due to breast cancer - a case report