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Chemical and biological analysis based on microand nanofluidic systems have been investigated intensively because of such favorable properties as sample, reagent, waste, and space reductions. In the systems, two-phase flows were utilized for such chemical/biochemical applications as extractions and reactions. Since the specific interfacial area (surface-to-volume ratio) increases with confinement, the fluid interface between the two phases plays greater roles in the operations in micro/nano confined spaces than in laboratory-scale instruments. Fluid-interface measurement techniques for revealing molecular transport and interfacial properties are necessary for appropriately designing integrated twophase operation. However, few methods exist for the interface in micro/nano-systems. In this article, we investigated an optofluidic method for measuring the interfacial tension in micro/nano confined spaces based on capillary wave resonance and laser light scattering.

Microfluidic Resonance of Capillary Waves and Surface Tension Measurement