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This study aimed to evaluate the optimum formulation of a niosomal nano-emulsion system consisting of silicone oil, non-ionic surfactant, and polyol. The nano-emulsions were prepared through a two-step homogenization procedure by a homogenizer and microfluidizer. The experiments were carried out by changing the composition ratio of dimethicone (DC200/100cs), polyglyceryl-2 dioleate, and glycerin, respectively. The variation of dimethicone resulted in showing a tendency for the content and particle size to be proportional. The variation of polyglyceryl-2 dioleate and the glycerin variation resulted in showing a similar tendency of the content and particle size to be inversely proportional. In zeta potential measurement, all nano-emulsions marked absolute value over around 30 mV, which is considered to be stable, while no significant correlation was observed with the variation. Based on these verifications, the author proposes the optimal conditions for preparing niosomal nano-emulsions.

Nano-emulsion system consisting of non-ionic surfactant, silicone, and polyol