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In this study 50 chronic renal failure patients were tested for blood ABO groups and for the presence of lymphocytotoxic antibodies against a panel of 20 donor lymphocytes (of known HLA types) using microcytotoxicity assay. The influence of other factors affecting sensitization, such as number of blood transfusions, pregnancies and previous graft rejections were analyzed too. The results showed that41.2 % of blood group 0 patients, 61.1 % of group A I, 90% of group B, and 80% of group A IB are sensitized (PRA> 10%). These results pointed to higher incidence of sensitization in patients with blood groups Band A IB as compared to groups A I and 0 . Our data suggest an impact of the ABO system on the sensitization phenomenon.

The influence of ABO blood groups on sensitization of potential kidney transplant recipients