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Background: Cardiovascular disease is a major cause of morbidity and mortality in hemodialysis patients, there is increasing evidence that platelets are major contributors to atherosclerosis, which is mediated through F11 receptors. Methods: Our study included 40 hemodialysis patients divided into two groups: Group 1: included 20 hemodialysis patients with ischemic heart disease (IHD), Group 2: included 20 hemodialysis patients without ischemic heart disease, they were compared with 20 age and sex matched controls, soluble F11 receptor (sF11R) and high sensitivity C-reactive protein (hs-CRP) were measured by enzyme-linked immunosorbent assay (ELISA). Results: sF11R was significantly higher in hemodialysis patients than controls; it showed significant difference between group 1, group 2 patients and controls. sF11R showed significant positive correlation with hs-CRP . Conclusion: sF11R can be considered a marker of IHD in hemodialysis patients.

Relationship between soluble F11 receptor and ischemic heart disease in hemodialysis patients