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Restless legs syndrome (RLS) is one of the sleep disorders which affects sleep stages and causes repetitive awakenings. The patho physiology of RLS is not well defi ned, but there are some evidences about the role of iron defi ciency in these patients. Therefore, in the current research we investigated the frequency of iron defi ciency anemia in such cases. 143 patients referred to Hamedan University of Medical Sciences associated Hospital within the year 2015 with hypoferritinemia underwent a cross sectional study. All collected data were classifi ed and analyzed by SPSS 16; t-test and chi-square tests. Of the 143 hypoferritinemic patients; 39 patients (27.3 %) met RLS criteria. Of that 17 cases (43.58 %) were male and 22 persons (56.41 %) were female. According to the study restless legs syndrome was signifi cantly more common in women than men.(P-value = 0.01). Restless legs syndrome was signifi cantly associated with serum ferritin levels in both sexes. And serum ferritin was signifi cantly lower in men and women with non-infected people. (P-value <0.01). RLS was signifi cantly more common in females than males. RLS was signifi cantly higher in low ferritin levels. On the other hand its relation with low serum ferritin in both males and females is signifi cant.

Association of hypo ferritinemia and restless legs syndrome in patients with iron de ciency anemias