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Cutaneous leishmaniasis (CL) is a worldwide public health and a social problem in many developing countries. The main objective of this study was to investigate the relationship between interleukin 4 (IL-4) gene promoter polymorphisms and leishmanial infected people in endemic focus of zoonotic cutaneous leishmaniasis (ZCL), in north east of Iran. In order to determine of polymorphism of interleukin 4 (IL-4) among patients with different clinical symptoms, fi fty human blood samples were prepared. All cases were classifi ed into fi ve groups including: cases with sever and ≤ 2 lesions, cases with ≥ 2 lesions, cases with treatment duration of less than two months, cases with treatment duration of more than two months and healthy samples with no signs. All 50 human samples were tested by PCR and followed using restriction enzyme of Eco47I. Our study revealed that Eco47I RE could cut the PCR product to an 18 bp and 177 bp if the SNP was C. Among the 50 PCR products we found 4 samples (8%) with CT allele and also 1 sample(2%) with TT allele. The rest of samples (90%) were CC. In conclusion, there was a signifi cant difference on frequencies of three alleles (CC, CT, TT) in studied group (2=56.4; df=2 ; p=0.000).

Relationship between interleukin 4 gene promoter polymorphisms and cutaneous Leishmaniasis cases in North Eastern Iran