Combined Food (Bekatul dan Lemak) Menurunkan Kadar Kolesterol Total, Trigliserida, dan LDL pada Tikus Galur Wistar

Rice bran is a food source that has potential to lower the cholesterol because of the high content of dietary fiber and bioactive components such as oryzanol, phytosterols, tocopherols, and tocotrienols. The purpose of this research is to analyze the provision of rice bran and high cholesterol diet on total cholesterol, triglycerides, and LDL in wistar strain rats. This is an experimental research with a randomized post-test only control group design. In this research, 25 wistar strain rats were divided randomly into 5 groups and were treated for 4 weeks. Group (K-) was given a standard diet, K(+) was given a standard diet and high cholesterol, (P1) was given a standard diet, high cholesterol and 10% rice bran, (P2) was given a standard diet, high cholesterol and 30% rice bran, (P3) was given a standard diet, high cholesterol and 50% bran. Total cholesterol level was measured using the CHOD-PAP method, triglyceride using the GPO-PAP method and LDL usinga homogeneous assay method. Data were analyzed using One Way ANOVA and Tukey HSD. Simultaneous provision of rice bran and high-cholesterol diet lowered total cholesterol levels significantly (p=0,000), triglycerides (p=0,001) and LDL (p=,048) compared to hypercholesterol dietary conditions. Rice bran dose of 50% (P3) provides a significant reduction in the levels of cholesterol, triglycerides, and LDL up to as same as the normal condition. Rice bran and high cholesterol diet simultaneously can reduce total cholesterol, triglycerides and LDL in wistar strain rats in which effective dose is 50% .