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Diabetes mellitus is one of the four priority non-infectious diseases in the world. Plant-based medicine is an alternative treatment with few side effects. Star fruit ( Averrhoa bilimbi L.) and bitter melon ( Momordica charantia L.) are plants that have anti-hyperglycemic activity. Hyperglycemia produces Reactive Oxygen Species (ROS) that make the β-cells of the pancreas necrosis that decreasing insulin synthesis. The anti-inflammatory activity appears based on the relative levels of CD4 + and CD25 + , which are TGF-β-producing regulatory T cells where TGF-β is a mediator that acts as an immunosuppressant. TGF-β would induce CD4 + T lymphocytes into T reg. The purpose of this study is to determine the profile of TGF-β on CD4 + and CD25 + spleenocytes on hyperglycemia mice after ABMC ( Averrhoa bilimbi Momordica charantia mix) treatment. Mice were divided into 5 groups, non-diabetic (N), hyperglycemia (H), hyperglycemia with extract doses of 10 mg.kg -1 BW (P1), 40 mg.kg -1 BW (P2), and 160 mg.kg -1 BW (P3). Diabetic mice were obtained after a single injection dose of 145 mg.kg -1 BW  streptozotocin  (STZ). The result showed that ABMC can reduce blood sugar levels faster and able reduce the number of CD4 + TGF-β + cells in hyperglycemia mice. Keywords: Averrhoa bilimbi L., CD4 + TGF-β + , CD25 + TGF-β + , hyperglycemia, Momordica charantia L.

The Study of Combination Ethanol Extract of Averrhoa bilimbi L. and Momordica charantia L. on CD4+CD25+TGF-β+ Spleenocytes of Hyperglycemia Mice