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Elephantopus scaber and Sauropus androgynus are herbal remedies that contain flavonoids as immunomodulatory agents. This study was aimed to observe the changes in the relative number of B cells in lymph node tissue of pregnant typhoid mice. Mice were divided into seven groups K-, K+, E. scaber 200 mg.kg -1 BW,  E. scaber 150 mg.kg -1 BW + S. androgynus 37.5 mg.kg -1 BW,  E. scaber 100 mg.kg -1 BW + S. androgynus 75 mg.kg -1 BW,  E. scaber 50 mg.kg -1 BW + S. androgynus 112.5 mg.kg -1 BW, dan S. androgynus 150 mg.kg -1 BW. Mice were dissected on the 12 th and 18 th day after herbal treatment. Data was analyzed using one way ANOVA (p < 0.05) and Duncan. The result show that E. scaber combination of 200 mg.kg -1 BW and E. scaber 150 mg.kg -1 BW + S. androgynus 37.5 mg.kg -1 BW can increase the number of B220 cells (p < 0,05) on pregnant mice typoid model. Keywords: B220, Elephantopus scaber , pregnant, Sauropus androgynus , typhoid fever

Bioactivity of Combination Elephantopus scaber and Sauropus androgynus on the Level of B220 cells of Lymph Node in Pregnant Typhoid BALB/c Mice