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In order to clarify the pathogenesis of lupus dermatoses and lupus nephritis, histamine degrading-enzyme activities in the skin and the kidney of MRL/Mp-lpr/lpr(MRL/1)mice were investigated, since the mice with lupus nephritis are the most attractive among several murine models from a der皿atopathological poillt of view because their skin lesions resemble very well to those of human SLE. In the dorsal lesional skin of MRL/1 mice, the specific activity of histamine-N-methyltransferase(HMT), the major histamine metabolizing enzyme in murine skin and kidney, was markedly lower than that in abdominal uninvolved skin. In addition, age-related analysis of HMT activity in the dorsal skin of MRL/Z mice revealed that the activity increased by age and was maximum at 1 or 2 months, and then decreased at 4 or 5 months when skin lesion appeared. However, HMT activity of the abdominal skin increased almost linearly by age. In contrast, histamine degrading-enzyme activity in kidney of MRL/l mice increased almost linearly by age. There were no differences between the HMT activities of

Effects of Corticosteroid on Histamine Degrading-enzyme Activities in Skin and Kidney of MRL/<i>l</i> Mice