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Prostaglandin El (PGEI), prednisolone (PSL) or both of them were administered to rats subcutaneously. Thereafter, numbers of polymorphonuclear leucocytes (PMN) in the peritoneal cavity of the rats stimulated with oyster-glycogen were counted and further Oi production of the peritoneal PMN was measured after stimulation of (PMNs) with the opsonized zymosan (OZ). PGEI inhibited the accumulation of PMN into the peritoneal cavity at doses ranging from 0.02 to 2 mg/kg, and also suppressed the 0Z production of PMN at doses ranging from 0.2 to 2 mg/kg. PSL inhibited both accumulation and Oz production of PMN at a dose of 4 mg/kg. The combined administration of PGEI and PSL inhibited more extensively both accumulation and OZ production of PMN than that of each drug alone. These results suggest that the anti-inflammatory effect of PSL could be accelerated by a combined use with PGEI.

nihon rinshō men'eki gakkai kaishi/nihon rinshou men'eki gakkai kaishi

Effects of PGE&lt;sub&gt;1&lt;/sub&gt; and prednisolone on accumulation and O&lt;sup&gt;-&lt;/sup&gt;&lt;sub&gt;i&lt;/sub&gt; production of PMN in the rat peritoneal cavity