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[Abstract] Stereotaxic infusion of LPS or your reagent of choice is an invaluable tool for the creation of chronic site-targeted lesions. Stereotaxic infusion of LPS has been used to establish chronic animal model of Parkinson’s disease, the most common neurodegenerative movement disorder. This protocol is especially useful to established chronic disease models and to study mechanisms of chronic central nervous system diseases.

Stereotaxic Infusion of LPS into Rat Substantia Nigra via Osmotic Minipump