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Malignant pleural mesothelioma (MPM) is a locally invasive tumour that rarely metastasises. Gastro-intestinal (GI) metastases from MPM are extremely uncommon. We present a case of a 73-year-old patient hospitalized for abdominal pain. Since a faecal occult blood test was positive, he underwent a colonoscopy identifying an intestinal adenocarcinoma. CT-scan showed a clinically asymptomatic right pleural tumour lesion histologically consistent with a MPM. A revision of the intestinal histology confirmed a metastasis from the MPM. The diagnosis of GIMPM metastasis is challenging as it can be clinically and radiologically misdiagnosed. It should be considered in any patient with MPM history.

Intra-luminal intestinal metastasis from malignant pleural mesothelioma