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Aging–related changes of the skin are characterized by reduction of the elasticity, moistness and thickness, appearance of wrinkles, pigmented spots, lentigos, and keratosis. Histological changes include thinning of epidermis, flattening of epidermal-dermal interface, reduction of production and disorganization of collagen and elastin, slowdown of cell turnover, reduction of melanocytes and their erratic activity and the phenomenon of solar elastosis. The objectives of the study were to evaluate the efficacy of mesotherapy with a cocktail containing combination of cell extracts from skin, placenta and mesenchyme with addition of collagen and elastin proteins in rejuvenation and revitalization of the facial skin. The cohort comprised of 26 women in the age 40-65 y.o. (mean age 56 ± 2.5) with Fitzpatrick skin types III and IV and Glogau score II-III. Treatment consisted of mesotherapy applied on the forehead, cheeks, periorbital and perioral areas, chin and neck. The injected formulation was MF+ Mito Organelles™ SPMCE – peptide-extracts from skin, placenta, mesenchyme, with collagen and elastin. Treatment sessions were performed across 12 weeks at weekly intervals. Final results were assessed 1 and 3 months after the last mesotherapy session using photographic comparison and patient’s subjective view and external dermatologist-expert’s opinion, clinical and instrumental evaluation, and histopathology report. Clinical and histochemical data obtained from the study confirms the anti-aging properties of the used product. Analysis of dermal elastic filaments has proven the reduction of skins roughness and determined the bio-revitalizing and rejuvenating effect of the used product. Study has demonstrated MF+ MO™ SPMCE capacity to promote biosynthesis of new collagen and elastic fibers. The improvements in skin hydration and dramatic reduction of senile lentigo and uneven pigmentation were noted. Obtained data allow to conclude that application of MF+ MO™ SPMCE cellular extracts/peptides in mesotherapy can be considered as safe and effective method of facial rejuvenation.

american journal of advanced drug delivery

Application of Cell Extracts from Skin, Placenta, Mesenchyme with Collagen and Elastin in Aesthetic Dermatology and Skin Revitalization: Evaluation of Outcomes in Cohort Study