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Chemotherapy of brain tumor by localized cerebral perfusion has been heretofore performed on 22 cases. In our series mean period from the onset of disease to the hospitalization was 5 months. The first group, 5 cases, received 100 mg. of Thio-TEPA during 30-40 min. of perfusion time. In this group side effects due to leakage of antitumor substance were severe and 3 cases died of the severest side effects. Mean survival period after perfusion therapy was 3 months in this group. In the second group, 7 cases, a half dose of Thio-TEPA or cytoxan was used in order to avoid the side effects. Mean survival period was 4.4 months. The third group, 10 cases, received 100 mg. of Thio-TEPA during 10 min. perfusion time. In this group side effects due to leakage factor were less severe than those of the first group. Eight cases of the third group are still alive. The longest survival period is 20 months after perfusion therapy and nearly 3 years after operation. Mean survival period was 10.4 months. According to the results mentioned above, the most excellent clinical results could be obtained by short time perfusion of high concentration of the antitumor substances. When each case is followed-up in detail, however, permanent effects could be hardly obtained by single perfusion therapy, even though improvement of general and neurological symptoms was temporarily observed and prolongation of the survival period was expected. Radiation therapy of brain tumor showed the similar insufficient effects as perfusion therapy. By means of the tissue culture screening test, the most effective antitumor substance can be used clinically, but radical therapeutic effect cannot be obtained by single perfusion therapy during short period.

26. Chemotherapy of Brain Tumor by Localized Cerebral Perfusion (IV)