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In 1956, Hayashi and Nagai showed that y-amino-f3-hydroxbutyric acid (GABOB), when introduced into cerebrospinal fluid, inhibited seizures which were produced by electrical stimulation of the motor cortex in dogs. We tried to apply GABOB to the epileptic patients by means of lumbar puncture and obtained the following results; complete inhibition of seizure 13 (59%), improved 6 (27%), and unchanged 3 (14%) among 22 patients.

160. A Study of the Serum Proteins of Cerebrospinal Fluid in Epilepsia by Means of Polarography and Paper Electrophoresis