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Chronological changes in regional cerebral blood flow (rCBF) and in the regional cerebral metabolic rate for glucose (rCMRGlu) were studied by a double tracer autoradiographic method in regions of local ischemia in rabbit brains. Local ischemia was produced by cautery of the bilateral vertebral artery, followed several days later by cautery of the left middle cerebral artery through a transorbital approach and ligation of the left common carotid artery. Autoradiography was performed, 2 hours, 6 hours, and 4 days after occlusion, by a double tracer method involving the use of 14C-iodo-antipyrine and 18F-fluoro-deoxyglucose. Absolute rCBF values were estimated by Sakurada's method and rCMRGlu values by Hutchins' formula. Histological examination was performed concurrently with the rCBF and rCMRGlu study. Mildly ischemic lesions (rCBF of 25 to 40 ml/100 g/min) were detected in the superior portion of the left frontal lobe, the left parietal lobe, and the left occipital lobe. Severely ischemic lesions (rCBF below 25 ml/100 g/min) were found in the lateral part of the left frontal lobe, the left temporal lobe, and the left caudate nucleus. In the mildly ischemic regions, rCMRGlu decreased in proportion to the decrease in rCBF. That is, matched low perfusion was observed, but there were no histological abnormalities. In severe ischemia the situation was quite different. Two hours after occlusion, most areas showed a decrease in rCMRGlu in proportion to the decrease in rCBF. However, 6 hours after occlusion, rCMRGlu decreased nonuniformly: in some places the decrease was dramatic and in others, rCMRGlu residue was found. Four days after occlusion, the reduction in rCMRGlu was again proportional to the rCBF decrease.(ABSTRACT TRUNCATED AT 250 WORDS)

The Chronological Change of the Cerebral Blood Flow and the Cerebral Metabolic Rate for Glucose in the Ischemic Rabbit Brain