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espanolThe aim of this study was to evaluate the effects of administration of tamoxifen (Tx) and its vehicle, soybean oil (SO), during the critical period of hypothalamic sexual differentiation in newborn male rats in the context of gonadal histomorphology during adulthood. The animals were randomly divided into 3 groups (n = 5 each). One hour after birth, one group was treated subcutaneously with 200 µg of Tx using commercial SO (20 µL) as a vehicle, another group was treated with only 20 µL of SO, and the control group received no treatment. All rats were weighed and sacrificed by cervical dislocation on day 90 post-treatment. Testicles were removed, weighed and processed for histological evaluation. The single administration of Tx and/ or SO during the critical period of sexual differentiation of the hypothalamus permanently altered testicular histomorphology, spermatogenesis, and body weight in adulthood. Alterations included vacuolization and reduction in the number of spermatogonia and Sertoli cells. The administration of Tx reduced testicular weight, the diameter and area of the seminiferous tubules, and the height of the germinal epithelium and increased the intertubular space. Soybean oil by itself reduced the number of spermatocytes and spermatids to a greater extent than Tx. There was no effect on the number of Leydig cells. The possibility that soybean oil can act as an endocrine disruptor deserves greater attention and opens the possibility for the development of new pest control methods MultipleEl objetivo de este estudio fue evaluar el efecto de la administracion de tamoxifeno (Tx) y aceite de soya (SO) durante el periodo critico de la diferenciacion sexual hipotalamica en ratas macho recien nacidas, en el contexto de la histomorfologia gonadal durante la edad adulta. Los animales se dividieron al azar en tres grupos (n = 5 cada uno). Una hora despues del nacimiento, un grupo fue tratado por via subcutanea con 200 µg de Tx y 20 µL de SO comercial como vehiculo; mientras otro grupo fue tratado solo con 20 µL de SO, y el grupo control no recibio ningun tratamiento. Todas las ratas se pesaron y sacrificaron por dislocacion cervical a los 90 dias postratamiento. Se extrajeron los testiculos, se pesaron y procesaron para la evaluacion histologica. La administracion unica de Tx y de SO durante el periodo critico de la diferenciacion sexual del hipotalamo altera de forma permanente la histomorfologia testicular, la espermatogenesis y el peso corporal en la edad adulta. Las alteraciones incluyen: vacuolizacion, reduccion del numero de espermatogonias y de celulas de Sertoli. La administracion de Tx redujo el peso testicular, el diametro y el area de los tubulos seminiferos, asi como la altura del epitelio germinal, e incremento el espacio intertubular. El SO redujo el numero de espermatocitos y espermatides, incluso mas que el Tx. No se afecto el numero de celulas de Leydig. La posibilidad de que el aceite de soya actue como disruptor endocrino, amerita mas atencion y abre la posibilidad para el desarrollo de nuevos metodos de control de plagas

A single neonatal administration of soybean oil and/or tamoxifen affects permanently the testis histomorphology in adult rats.