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Chickpea seeds are the preferred source of proteins possessing health care functions in countries across the world. In the present investigation, the chickpea seed protein subjected to enzymatic hydrolysis produced bioactive peptides that were able to inhibit the angiotensin converting enzyme (ACE) and cytotoxic effect. Experimental screening was to test the efficacy of hydrolytic enzymes in chickpea seed for production of bioactive peptides was therefore carried out. The optimum hydrolysis times for each protein hydrolysate prepared by alcalase was at 2 h which inhibited ACE-I. The ACE-I inhibitory activity (lowest IC50) was observed with IC50 value 52.22 µg/ml and the cytotoxicity assessment for the protein hydrolysate was subjected to antiproliferative evaluation for breast cancer cell lines of MCF-7 and MDA-MB-231. The IC50 of alcalase hydrolysate was 0.71 mg/ml and 0.78 mg/ml in MCF-7 cells and MDA-MB-231 respecctively. Study indicated the potential of chickpea proteins as a source of ACE-inhibitory and antiproliferative potential for open up new vista to foresee the application of chickpea proteins into functional foods.

Angiotensin-I converting enzyme (ACE-I) inhibitory and antihypertensive potential of chickpea seed protein hydrolysate