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Mustafa Gülfen*, Yazgı Canbaz and Abdil Özdemir Department of Chemistry, Faculty of Arts and Sciences, Sakarya University, 54187 Sakarya, Turkey. *Coressponding Author Email: mgulfen@sakarya.edu.tr Received 09 March 2020, Revised 10 June 2020, Accepted 15 June 2020 Abstract A ratio first order derivative zero crossing UV-Visible (UV-Vis) spectrophotometric method has been developed for the simultaneous determination of amoxicillin (Amox), levofloxacin (Levo) and lansoprazole (Lanso). The method was validated for the mixtures of Amox, Levo and Lanso in the standard solutions and pharmaceutical tablets. Amox, Levo and Lanso solutions prepared in MeOH:H2O (50:50 v/v) solvent mixture were used in the measurements. The calibration graphs were prepared at the wavelengths of 248.9, 219.4 and 262.8 nm, respectively, which were determined as the zero crossing points of the ratio – first order derivative spectra of them. The calibration curves were optimized linearly between the concentrations of 1.22 15.0 mg/L for Lanso, 0.95 20.0 mg/L for Levo and 3.42 40 mg/L for Amox together with the correlation coefficients (R) 0.9996, 0.9993 and 0.9987, respectively. The limits of detection (LODs) of the improved method were  1.03 mg/L concentration, and the limits of quantification (LOQs) were  3.42 mg/L. The proposed ratiofirst order derivative zero-crossing method was validated with good accuracies as the recoveries of 100.0%, 102.5% and 99.2% and with high precisions as the RSDs % of 1.37, 2.04 and 2.64 for Amox, Levo and Lanso, respectively. It was shown that the Amox, Levo and Lanso can be determined simultaneously without any separation in pharmaceutical mixture formulations.

Ratio - First Order Derivative - Zero Crossing UV-Visible Spectrophotometric Method for Analysis of Amoxicillin, Levofloxacin and Lansoprazole Mixture