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Complex regional pain syndrome type I (CRPS-I) is an affliction that can occur after trauma to an arm or leg. It is characterized by a combination of autonomous, sensory and vasomotor symptoms. The pathogenesis of CRPS is not clear, nor is there a definitive treatment for this syndrome. The morbidity and costs in health care justify the search for a means to prevent CRPS. The diagnosis is made clinically and CRPS occurs relatively frequently after wrist fractures and most often in females. Vitamin C (ascorbic acid) is a watersoluble vitamin that protects against scurvy and it acts as a strong anti-oxidant. By scavenging radicals, vitamin C halts free-radical reactions and prevents the propagation of chain reactions. In this way vitamin C protects the capillary endothelium and circulating cells. The results of our two RCTs comparing vitamin C and placebo in the prevention of CRPS after distal radial fractures, were pooled for the analysis of the occurrence of CRPS. It is concluded that vitamin C reduces the chance on the occurrence of CRPS-I after wrist fractures, if it is started on the day of the fracture in a dose of 500 mg per day during 50 days.

the open conference proceedings journal

The Administration of Vitamin C in Prevention of CRPS-I After Distal Radial Fractures and Hand Surgery – A Review of Two RCTs and One Observational Prospective Study