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Aptamers, also known as chemical antibodies, are short single-stranded DNA, RNA or peptide molecules.  These molecules can fold into complex three-dimensional structures and bind to target molecules with high affinity and  specificity. The nucleic acid aptamers are selected from combinatorial libraries by an iterative in vitro selection procedure  known as systematic evolution of ligands by exponential enrichment (SELEX). As a new class of therapeutics and drug  targeting entities, bivalent and multivalent aptamer-based molecules are emerging as highly attractive alternatives to  monoclonal antibodies as targeted therapeutics.  Aptamers have several advantages, offering the possibility of overcoming limitations of antibodies: 1) they can be  selected against toxic or non-immunogenic targets; 2) aptamers can be chemically modified by using modified nucleotides  to enhance their stability in biological fluids or via incorporating reporter molecules, radioisotopes and functional groups  for their detection and immobilization; 3) they have very low immunogenicity; 4) they display high stability at room  temperature, in extreme pH, or solvent; 5) once selected, they can be chemically synthesized free from cell-culturederived  contaminants, and they can be manufactured at any time, in large amounts, at relatively low cost and  reproducibly; 6) they are smaller and thus can diffuse more rapidly into tissues and organs, leading to faster targeting in  drug delivery; 7) they have lower molecular weight that can lead to faster body clearance, resulting in a low background  noise for imaging and minimizing the radiation dose to the patient in diagnostic imaging. Thus, the high selectivity and  sensitivity, ease of screening and production, chemical versatility as well as stability make aptamers a class of highly  attractive agents for the development of novel therapeutics, targeted drug delivery vehicles and molecular imaging.  In the review, we will discuss the latest technological advances in developing aptamers, its application as a novel class of  drug on its own, as well as in surface functionalizationFull Tex

Aptamer Therapeutics: The 21st Century`s Magic Bullet of Nanomedicine