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We have shown that Atp10c, a type 4 P-type ATPase, is a strong candidate affecting glucose and lipid metabolism in humans and mice. Atp10c is a putative phospholipid translocase associated with cell signaling and intracellular protein trafficking. In order to examine the biological role of Atp10c, semiquantitative reverse transcriptase - polymerase chain reaction was carried out. Atp10c mRNA is expressed in 3T3-L1 cells and in primary preadipocytes and adipocytes generated from mice. Atp10c mRNA is regulated during fat cell differentiation and modulated by PPAR agonists and antagonists as well as by hormonal factors (insulin and dexamethasone). Atp10c expression is regulated by both the process of adipocyte differentiation and by effectors of fat and glucose metabolism. Taken together these data along with the published phenotype of the Atp10c heterozygote mice suggest that ATP10C is a newly identified protein with a possible biological role in the development of obesity and obesity-related metabolic disorders.

PPARγ Agonists Down-Regulate the Expression of Atp10c mRNA during Adipogenesis