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The antinociceptive activity of mycelial extract from fermented mushroom of Ganoderma lucidumCoprinus comatus and Grifola frondosa were studied in this paper. The writhing test, formalin test and hot-plate test were used to evaluate the antinociceptive activity of the acetone extracts of the three Species of Fungi of Basidiomycetes in the study respectively. The extract of Ganoderma lucidum inhibited in a dose-dependent manner the acetic acid-induced abdominal constrictions in mice (p<0.05). Also both phases of the response were significantly inhibited in the formalin test (p<0.05). In the hot-plate test, results showed that extract of Ganoderma lucidum significantly inhibited the reaction time to thermal stimuli at 30, 60, and 90 min (p<0.05). The preliminary toxicologic study demonstrated the safety of it. However the ex- tract from fermented mushroom of Coprinus comatus and Grifola frondosa did not show significantly expectative antino- ciceptive effect. Our results show the acetone extract of Ganoderma lucidum is a potent analgesic drug.

A Comparison of Antinociceptive Activity of Mycelial Extract from Three Species of Fungi of Basidiomycetes