English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Purpose: To investigate the impact of quantitative FDG-Metabolic activity of non-iodine avid Loco-regional recurrence (LRR; thyroid recurrence and/or cervical node metastasis) on therapy selection in thyroid cancer patients with elevated thyroglobulin (TG). Methods: Forty thyroid cancer (33 papillary and 7 follicular) patients who underwent FDG PET/CT were studied (with TSH>30 mU/L). Those with only LRR were classified according to maxSUV (cut-off level 5) into high and low metabolic activity lesions (HMA L their therapy outcome was compared with histopathologic findings and/or follow-up routine evaluation. Results: Only LRRs was found in 20 patients (17 papillary and 3 follicular) with diagnostic accuracy of FDG PET/CT of 100 %. 14/20 patients belonged to HMA where surgical neck exploration was done while in the remaining 6 patients with LMA empirical high dose of radioactive iodine-131 was given based on the assumption of the presence of a mixture of undifferentiated and differentiated thyroid cancer cells; though their post-therapy scan was negative but declined TG- levels were elicited in their follow-up (base-line 27.7±2.4 and at follow-up 6.8±1.4 ng/ml; P 0.02). Conclusion: Max-SUV based classification of non-iodine avid LRR might improve the diagnostic accuracy FDG PET/CT in a therapeutically relevant way in DTC-patients by precisely localizing them with subsequent surgical guidance in HMA lesions while those with LMA could benefit from further RA-131 therapy.

Low FDG Metabolic Activity of Loco-Regional Recurrence in Thyroid Cancer Patients; Is Iodine-131 has a Potentiality?