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Background: The prevalence of obstructive coronary artery disease (CAD) in patients with diabetes mellitus and hypothyroidism versus a control group of patients with diabetes mellitus without hypothyroidism undergoing coro- nary angiography needed to be investigated. Methods: Coronary angiography was performed on 173 patients with diabetes mellitus and hypothyroidism and in a con- trol group of 179 patients with diabetes mellitus without hypothyroidism because of a recent myocardial infarction or un- stable angina (48% of both groups) or chest pain with a positive stress test (52% of both groups). Obstructive CAD was diagnosed if there was >50% obstruction of at least 1 major coronary artery. Results: >50% narrowing of 1 or more major coronary arteries was present in 145 of 173 patients (84%) with diabetes with hypothyroidism and in 132 of 179 patients (74%) with diabetes without hypothyroidism (p 50% narrowing of 3 major coronary arteries was present in 69 of 173 patients (40%) with diabetes with hypothyroidism and in 39 of 179 patients (22%) with diabetes without hypothyroidism (p<0.001). Conclusions: In conclusion, patients with diabetes mellitus with hypothyroidism have a higher prevalence of obstructive CAD of 1 or more major coronary arteries and of 3 major coronary arteries than patients with diabetes without hypothyroidism.

Prevalence of Obstructive Coronary Artery Disease in Patients With Diabetes Mellitus with and without Hypothyroidism