English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Stem cells can be found in embryonic and extraembryonic tissues as well as in adult organs. In particular,\udresearch in the last few years has delineated the key features of perinatal stem cells derived from fetus-associated tissues.\udThese cells show multiple differentiation potential, can be easily expanded ex vivo, and raise no ethical concerns as\udregards their use. Several reports indicate that cells isolated from Wharton's jelly (WJ), the main component of umbilical\udcord extracellular matrix, are multipotent stem cells that express markers shared by other mesenchymal stem cells (MSC)\udand give rise to different mature cell types belonging to all three germ layers. Moreover, WJ-MSC display promising\udhypoimmunogenic and immunomodulatory properties, since they express molecules able to modulate NK cells and\udexpand regulatory T-cell populations.\udIn this review, we focus on the use of perinatal stem cells for regenerative medicine aimed at cartilage repair and\udregeneration. Cartilage is a specialized connective tissue which has poor regeneration and self-repair capacity in vivo.\udTraumatic injury or autoimmune processes are among the main causes of cartilage damage and degeneration, for which\udnew hope comes from tissue engineering using stem cells which have undergone chondrocyte-like differentiation. We\udanalyze the in vitro and in vivo data on the use of perinatal stem cells, in particular WJ-MSC, for cartilage regenerative\udmedicine. The high variability of cell sources, the use of different types of scaffolds and matrixes, and the administration\udof several combinations of growth factors clearly point out the need for further research to optimize this cellular therapy\udapproach and translate the results obtained from bench to clinic

Perinatal and Wharton's Jelly-Derived Mesenchymal Stem Cells in Cartilage Regenerative Medicine and Tissue Engineering Strategies