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Background: Misinterpretation of medications instructions due to poor health literacy is common in diabetic patients, leading to suboptimal medication therapy. The aim of this study was to investigate patients’ interpretation of prescribed medication instructions at a selected Clinic in the Capricorn District of Limpopo Province, South Africa. Methods: The study used a qualitative research approach. Non-Probability purposive sampling was used to select five participants for the study. Semistructured interviews with a guide were used to collect data. Tesch’s steps for qualitative data analysis were adopted. Results: The study findings revealed inadequate explanation of instructions, poor health outcomes, lack of information related to poor health outcomes, lack of knowledge on using the medication correctly, and medication noncompliance. The findings imply that there is poor education regarding medication use by diabetic patients. Conclusion: The study indicated that diabetic patients have poor medication instructions comprehension such as an inadequate explanation of the medication instructions. Therefore, healthcare professionals must provide in-depth explanation of medication instructions to enhance comprehension.

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The Interpretation of Prescribed Medication Instructions by Diabetes Mellitus Patients at a Selected Clinic in the Capricorn District of Limpopo Province, South Africa: A Pilot Study