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This study examined the dynamics of muscle oxygenation during exercise between chronic obstructive pulmonary disease (COPD) patients and age-matched healthy controls. Oxygen saturation of the vastus lateralis muscle (SmO2) was measured during incremental cycle exercise in 11 patients with exercise intolerance below the anaerobic threshold (AT) workload (COPD-AT(-)), 11 patients with exercise intolerance above the AT workload (COPD-AT(+)), and 8 controls by using near-infrared spectroscopy. Despite lower peak workload in COPD patients than in controls, trough SmO2 in COPD-AT(-) patients was significantly lower than SmO2 at the AT workload in controls, and was the same level as trough SmO2 in COPD-AT(+) patients and trough SmO2 in controls. The decrease of SmO2 was correlated with forced expiratory volume in one second % in COPD-AT(+) patients, and with exercise-induced hypoxemia in COPD-AT(-) patients. In conclusion, muscle oxygenation status deteriorates more steeply during exercise in COPD patients than in age-matched controls. Such severe impairment of muscle oxygenation in COPD patients may be affected by the impairment of lung function caused by COPD.

Impaired Muscle Oxygenation During Incremental Cycle Exercise in COPD Patients Compared with Age-Matched Healthy Subjects