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In recent years, several new methods have emerged for rapid NMR data collection. One class of methods is projection NMR spectroscopy, which involves phase sensitive joint sampling of two or more chemical shifts in an indirect dimension of a multidimensional NMR experiment. In the current implementations of this method, cosine/sine modulation of all chemical shifts involved in the joint sampling are collected and stored as separate FIDs. A post-acquisition data processing step (application of G-matrix) then separates the different inter-modulations of chemical shifts. Thus, joint sampling of K+1 spins results in 2 K combination of chemical shifts (also representing 2 K projection angles). One limitation of this approach is that even if only a few of the 2 K components of the multiplet (or projection angles) is desired, an entire data set containing information for all 2 K shift combinations is collected. We propose here a simple method which releases this restriction and allows one to selectively detect only the desired linear combination of chemical shifts/projection an- gles out of 2 K combinations in a phase sensitive manner. The method involves selecting the appropriate cosine/sine modu- lations of chemical shifts and forming the desired linear combination by phase cycling of the radiofrequency pulses and receiver. This will benefit applications where only certain linear combination of shifts are desired or/and are sufficient. Further, G-matrix transformation required for forming the linear combination is performed within the pulse sequence. This avoids the need for any post-acquisition data processing. Taken together, this mode of data acquisition will foster new applications in projection NMR spectroscopy for rapid resonance assignment and structure determination.

A Method to Selectively Observe a Desired Linear Combination of Chemical Shifts in GFT Projection NMR Spectroscopy