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Sprague Dawley rats (200 ± 20g) were used as experimental animals. Animal models like Freund’s Adjuvant (FA) induced inflammation, Monosodium Iodo Acetate (MIA) induced osteoarthritis and Potassium Oxonate Induced Uricemia (POU) were used for the study. Total Leukocyte Count (TLC) and Differential Leukocyte Count (DLC) and Tumor Necrosis Factor (TNF-α) were assessed in the blood of rats. The dose of 200 mg/kg of the ethanolic extract of Cissampelos pareira (CPE) and Stephania glabra (SGE) was recorded as the safe dose.

Anti-Arthritics Activity of Cissampelos pareira Leaves and Stephania glabra Rhizome Ethanolic Extract on Adjuvant and Potassium Oxonate Treated Rat