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In the last eight decades after the first human influenza virus was isolated by Smith et al. [3], huge progress has been made in studying, preventing and treating influenza at that time. Replication cycle of influenza viruses, genome structure, evolution, pathogenesis, mechanisms of the immune response to virus infection, epidemiology of influenza, its express diagnostics, clinical course, and complications, were discovered in detail. Full genome sequencing and reassortment by reverse genetics became routine techniques.

Will We Ever be Able to Defeat Human Influenza?