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Objective: The study was designed to describe a cohort of patients with ischemic colitis (I.C.) that required ad- mission and the factors related to severity and mortality. Also, we tried to define the risk of relapse after discharge and the variables associated. Methods: Descriptive and retrospective study of patients with I.C. diagnosed between January 1996 and March 2003. Qualitative variables were analyzed using Fisher exact test and parametric variables were analyzed using Students t-test. Those variables statistically significant were included in a Cox regression model. Results: During the study period, 169 patients with I.C. were admitted into hospital. Ten patients required surgery, 8 pa- tients died and 13 were considered severe. The variables independently associated to severity were: cerebrovascular dis- ease (OR: 6.63, 95% CI: 1.59-27.61, p: 0.009), absence of hematochezia (OR: 4.43, 95% CI: 1.12-17.47, p: 0.033), ab- dominal distention (OR 6.39, 95% CI: 1.65-24.70, p: 0.007) and ileus (OR 8.76, 95% CI: 2.12-36.06, p: 0.003). Only dif- fuse peritonism was associated to mortality (OR: 26.07, 95% CI: 5.67-119.93, p<0.001). After discharge, seven (4.5%) patients had a relapse (mean time: 5.31t3.67 months), with a stricture in 6 of them. A second episode of I.C. (OR: 13.21, 95% CI: 2.52-69.28, p: 0.002), treatment with aspirin (OR 6.41, 95% CI: 1.12-36.64, p: 0.037) and with antihypertensive drugs (OR 0.089, 95% CI: 0.01-0.754, p: 0.027) were independently associated to relapse. Conclusions: We identified several predictive factors that can be used to stratify patients on admission. We found a rela- tion between treatment with aspirin, antihypertensive drugs and relapse that should be confirmed in prospective studies.

Ischemic Colitis: Characteristics and Predictive Factors of Severity, in Hospital Mortality and Relapse