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The synthesis of various substituted Biginelli 3,4-dihydropyrimidinone/thione and Hantzsch 1,4- dihydropyridine derivatives has been achieved using a modified procedure in the presence of potassium ter-butoxide (t- BuOK) as a catalyst under solvent-free conditions, in good to excellent yields.

the open organic chemistry journal

A One-pot Multi-component Synthesis of Dihydropyrimidinone/Thione and Dihydropyridine Derivatives via Biginelli and Hantzsch Condensations using t-BuOK as a Catalyst Under Solvent-free Conditions