English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The present work provides a brief review about evidence obtained in the past years mainly in our laboratory using the mouse model, that germ cells and gonadal somatic cells may be direct target of endocrine disruptors (EDs) from very early stages of gonad formation. Since it is now known that epigenetic pathways are crucial for germ-line development and that EDs are also able to interfere with epigenetic mechanisms. We will discuss these results mostly in light of possible effects by such molecules on the epigenoma of the primordial germ cells (PGCs), the precursors of the adult gametes that transmit genetic information between generations.

Epigenetic Reprogramming in the Mammalian Germ Line: Possible Effects by Endocrine Disruptors on Primordial Germ Cells