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A quartz crystal microbalance was used for real-time monitoring of fibrinogen cross-linking on three model biomaterial surfaces. Fibrinogen adsorbs slowly and forms a less rigid multi-layer on hydrophobic surfaces, while it ad- sorbs quickly, forming a single mono-layer on hydrophilic surfaces. The extent of fibrinogen cross-linking is greater on hydrophobic surfaces. Fibrinogen cross-linking can also rigidify the relatively soft coatings of poly(methyl methacrylate) and dodecanethiol self-assembled monolayer.

Real-Time Monitoring of Fibrinogen Cross-Linking on Model Biomaterial Surfaces with Quartz Crystal Microbalance