Open AccessEffect of the Metal Center on the Antitumor Activity of the Analogous Dinuclear Spermine Chelates (PdCl2)2(Spermine) and (PtCl2)2(Spermine)
Author(s) -
Ana Soares,
Sónia M. Fiuza,
M. Sameiro T. Gonçalves,
Luís A. E. Batista de Carvalho,
M. Paula M. Marques,
Ana M. Urbano
Publication year - 2007
Publication title -
letters in drug design and discovery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.223
H-Index - 33
eISSN - 1875-628X
pISSN - 1570-1808
DOI - 10.2174/157018007781788516
Subject(s) - spermine , chemistry , polyamine , chelation , cisplatin , cytotoxic t cell , intracellular , stereochemistry , metal , biochemistry , in vitro , organic chemistry , enzyme , biology , genetics , chemotherapy
The cytotoxic activity of (PdCl2)2(spermine) against a human cancer cell line (HSC-3) was evaluated. The re- sults show an activity higher than that of the analogous Pt(II) chelate and, for 24 h incubations, identical to that of cis- platin. They also suggest a faster intracellular uptake and DNA binding relative to cisplatin.
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