Open AccessA Mitochondrial Approach to Cardiovascular Risk and Disease
Author(s) -
Caroline D. Veloso,
Getachew D. Belew,
Luciana Louzada Ferreira,
Luís F. Grilo,
John G. Jones,
Piero Portincasa,
Vilma A. Sardão,
Paulo J. Oliveira
Publication year - 2019
Publication title -
current pharmaceutical design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 159
eISSN - 1873-4286
pISSN - 1381-6128
DOI - 10.2174/1389203720666190830163735
Subject(s) - medicine , mitochondrion , dyslipidemia , disease , context (archaeology) , diabetes mellitus , insulin resistance , fatty liver , oxidative stress , bioinformatics , pharmacology , endocrinology , biology , paleontology , microbiology and biotechnology
Cardiovascular diseases (CVDs) are a leading risk factor for mortality worldwide and the number of CVDs victims is predicted to rise through 2030. While several external parameters (genetic, behavioral, environmental and physiological) contribute to cardiovascular morbidity and mortality; intrinsic metabolic and functional determinants such as insulin resistance, hyperglycemia, inflammation, high blood pressure and dyslipidemia are considered to be dominant factors.
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