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The three major objectives of this research were: (a) identification, (b) organization, and (c) analysis of mammalian repetitive DNA, as stated in the title. Our approach was based on computer-assisted analysis of sequence data complemented by small-scale experimental verification. Our major accomplishments include development of public database of repeats (Repbase Update) and of a server for automatic annotation of repetitive DNA, known as “CENSOR server”. Furthermore, we have made a major contribution towards understanding of the mechanism of retrotransposition of SINE and LINE elements which represent 25% of mammalian genomes.

Identification, organization and analysis of mammalian repetitive DNA. Final report