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Thirty-seven sterile materials of common construction usage, common lubricants, and samples of wearing apparel were injected as finely divided particles into the subcutaneous soft tissues of guinea pigs, each in six different sites. At intervals of 3, 7, 14, 21, 30, 65, or 90 days, an inoculation site of each material was excised, in toto, fixed, and examined microscopically. In addition, ten selected materials were injected into the liver and spleen and deposited on the omentum and mesentery of four guinea pigs for each material type. At intervals of 7, 14, 21, and 30 days, one of each group of four animals was sacrificed and a block of tissue containing the inoculum was removed from the tissues and organs, fixed, and examined histologically. The majority of materials induced only a mild and delayed inflammatory response followed by encapsulation at the end of 14 days and a relatively inert fibrous nodule produced by the 2lst or 30th day. Copper particles incited a marked inflammatory response with abscess formation which persisted until the 90th day, although showing signs of subsiding at this time. Cudmium lesions were characterized by a peculiar zone of necrosis about the particle aggregate which persisted until the 60thmore » day. Duraluminum of one type incited a pseudoneoplastic fibrous response. Axle grease, in the early stages, induced one of the most intense acute inflummations, in contrast to that produced by motor oil and ordinary lubricating grease, but the process had subsided and was fibrosed by the end of 30 days. (auth)« less

A STUDY OF THE TISSUE RESPONSE TO STERILE DEPOSITS OF PARTICULATE MATERIAL