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The hypotensive effects of an angiotensin II type 1 receptor antagonist TCV-116 were accelerated by swimming training in the early period of chronic administration in young rats. In the latter period, however, a severe decrease in blood pressure that appeared during long-term administration of TCV-116 was prevented by swimming training. Therefore exercise may contribute to the stabilization of blood pressure in young rats treated with TCV-116.

Hypotensive Effects of an Angiotensin 11 Type 1 Receptor Antagonist Differ between Exercised and Sedentary Rats Aged from 4 to 19 Weeks.