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Pentobarbital anesthesia led to a decrease of noradrenaline concentrations of both cisternal cerebrospinal fluid and plasma and adrenaline concentration of plasma with a concomitant decrease in blood pressure in rats. These data suggest that pentobarbital suppresses both central and peripheral noradrenergic nervous activity.

Decreases in Catecholamine Concentrations of Cisternal Cerebrospinal Fluid and Plasma in Rats Caused by Pentobarbital Anesthesia.