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When female analbuminemic rats were injected with 0.8 mg uric acid every 3 h, their survival time at 5 degrees C increased from 14 h to 28 h, but uric acid had no effect on analbuminemic male rats. When female rats were oophorectomized 1 week before cold exposure, the injection of uric acid had no effect on their survival. Furthermore, uric acid did not increase the survival of the female rats that were administered a pellet containing 5 mg testosterone 1 week before the cold exposure. When the male rats were castrated 1 week before cold exposure, their survival time decreased from 20 h to 14 h, and administrations of 5 mg estradiol pellet at the time of castration and 0.8 mg uric acid every 3 h during cold exposure increased their survival time to 23 h.

Sex differences in the effect of uric acid on the survival of analbuminemic rats exposed to cold: Effects of gonadal hormones and uric acid.