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Catecholamine secretion from the perfused cat adrenal in response to 15 mM KC1 or acetylcholine was significantly increased by treatment with active tumor promoters. A good correlation was found between potentiation of the secretory response and the phorbol ester receptor binding activity, suggesting that promoters modulate the secretory mechanism via the receptors.

Tumor promoters potentiate the adrenomedullary secretion induced by acetylcholine and excess K possibly by stimulating phorbol ester receptors.