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An ATPase preparation of cell membranes was obtained from pig thyroid gland and the effects of various thyroid-tropic substances on it were systematically studied in vitro. TSH had little effect in stimulating Na+, K+-activated ATPase even at very high concentrations. Physiologically active estrogens, 1715-estradiol, estriol and estrone, were found to stimulate the enzyme significantly even at extremely low concentrations. Progesterone was active only at high concentrations. Testosterone, cortisone, dexamethasone, iodide, iodotyrosines, iodothyronines and perchlorate were all without effect. Thiocyanate, thiourea, propylthiouracil and methylthiouracil were slightly, but consistently, effective in depressing the enzyme. It is likely that estrogens stimulate and goitrogens depress thyroidal iodide uptake by influencing directly the activity of thyroidal Nat, K+-activated ATPase.

EFFECT OF THYROID-STIMULATING HORMONE, ESTROGENS AND OTHER THYROID-TROPIC SUBSTANCES IN VITRO ON Na+, K+-ACTIVATED ATP-ASE OF PIG THYROID GLAND