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It is well known that hypothalamic tissues,especially the median eminence area contain a considerable amount of posterior pituitary hormones and several biologically active amines.In the search for specific neurohumor(s)regulating ACTH release,these substances have been claimed as such in the past decades. Among them,adrenaline was one and vasopressin another of the early candidates proposed for this role1,2).Many of the stimuli which can elicit the release of ACTH have been shown to be accompanied by the release of adrenaline from the adrenal medulla1)and of vasopressin from the posterior pituitary lobe in the other similar conditions2).Considerable evidence,however,was assembled against the view that either of these substances was itself the ACTH releasing neurohumor3).In fact, the potent ACTH-releasing substances,i.e.CRFs in the neurohypophysial extracts were separated from vasopressin,though they may be structurally related to it4,5).Nevertheless,uniqueness of vasopressin as a stimulus was emphasized by LEEMAN et al.6)as compared with other stressful stimuli.On the other hand,AKMAYEV and DoNATH7)showed recently that the catecholamines histochemically demonstrable in the median eminence area were increased by adrenalectomy and decreased by hydrocortisone administration, thus suggesting a possible involvement of these amines in the release of ACTH. Since the chemical nature of CRF has not finally been clear yet8,9),CRF potency of the test materials depends mainly on the adequacy of an assay method employed.In attempts therefore to elucidate the significance of the neurohypophysial hormones and several monoamines in the regulation of ACTH release,it is of considerable interest to re-examine CRF activities of these substances and their modes of action by use of the intrapituitary microinjection method,validation of which was already given in a previous paper10).In this

EFFECTS ON ACTH RELEASE OF INTRAPITUITARY INJECTIONS OF POSTERIOR PITUITARY HORMONES AND SEVERAL AMINES IN THE HYPOTHALAMUS