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It was shown that adrenalectomized dogs maintained with DCA easily succumb to shock in mild hypercalcemia due to an idiosyncratic hepatic engorgement similar to that observed in anaphylaxis. The induction of histamine release from the liver mast cells in the absence of glucocorticoid by calcium ions has been shown to be the cause.

INDUCTION OF ANAPHYLAXIS-LIKE SHOCK WITH CALCIUM IN DOGS IN THE ABSENCE OF GLUCOCORTICOID